Hedgehog pathway antagonists

Details Hedgehog pathway antagonists Hedgehog pathway antagonists

2004-09-29

2011-11-29

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S357000

Reexamination Certificate

active

08067608

ABSTRACT:
Aromatic compounds for treating various diseases and pathologies are disclosed. The methods use of such compounds are also provided. Accordingly, the present invention makes available methods and compositions for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function.

REFERENCES:
patent: WO 2004056774 (2004-07-01), None
Hcaplus 109:73373.
Hcaplus 1999:48617.
Patani, George, et. al., “Bioisosterism: A Rational Approach in Drug Design”, Chem. Rev. 1996, 3147-3176.
HCAPLUS 109:73373 1988.
Patani, George, et. al., “Bioisosterism: A Rational Approach in Drug Design”, Chem. Rev. , 3147-3176, 1996.
Hcaplus 1999:48617, “Preparation of N-[(aminoalkoxy)phenyl]benezamides and analogs as CCR5 receptor ligands”, Bondinell et. al., WO 9901127, Nov. 4, 1999.

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