Hedgehog interacting proteins and uses related thereto

Details Hedgehog interacting proteins and uses related thereto Hedgehog interacting proteins and uses related thereto

2006-10-03

2006-10-03

Spector, Lorraine (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C530S350000, C530S402000, C435S069700, C514S002600, C514S012200

Reexamination Certificate

active

07115394

ABSTRACT:
The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.

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