Heavy metal salts of succinic acid hemiesters with hyaluronic ac

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 53, 536 553, 424 173, 424 935, 424 943, A61K 3173, C08B 3700

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active

060179015

ABSTRACT:
Hyaluronic acid or hyaluronic acid ester derivatives, wherein one or more hydroxy functions of its 1,4.beta.-D-glucuronic acid and 1,3-.beta.-N-acetyl-D-glucosamine alternating repeating units are esterified with a carboxyl group of succinic acid to form the succinic hemiester of hyaluronic acid or hyaluronic acid esters. These derivatives are used to prepare the corresponding heavy metal salts of succinic hemiesters of hyaluronic acid or with hyaluronic acid partial or total esters. These salts are used as active ingredients in the preparation of pharmaceutical compositions to be used as antibacterial and disinfectant agents for the treatment of wounds, burns and ophthalmia or as antiinflammatory agents in particular for the preparation of pharmaceutical compositions for the treatment of osteoarticular disorders.

REFERENCES:
patent: 4746504 (1988-05-01), Nimrod et al.
patent: 4851521 (1989-07-01), della Valle et al.
patent: 5688931 (1997-11-01), Nogusa et al.
Liesegang, Survey of Opthalmology, "Viscoelastic Substances in Opthalmology", vol. 34, No. 4 (Jan. 1990-Feb. 1990).
Milanino et al., "Copper and Zinc in Inflammation", Inflammation and Drug Therapy Series, vol. IV, 1989. Month not available.
Database WPI Derwent, Japan A 54 036 388, Mar. 17, 1979.

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