Heat treatment of IgM-containing immunoglobulins to eliminate no

Details Heat treatment of IgM-containing immunoglobulins to eliminate no Heat treatment of IgM-containing immunoglobulins to eliminate no

1990-04-03

1993-10-26

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

424 858, A61K 39395, C07K 312, C07K 1506

Patent

active

052567710

ABSTRACT:
Mild heat-treatment of IgM antibody concentrates diminishes the potential to induce non-specific complement activation without significant loss of normal immunologic effector functions. These IgM immunoglobulin concentrates retain specific antigen binding properties and activate complement specific antigen binding properties and activate complement when bound to antigen. Preferred product includes at least 20% by weight IgM in an IgM/IgG antibody mixture. Heating is done at a temperature within the range of about 40.degree. C. to 62 .degree. C., preferably about 45.degree. to 55.degree. C., in a solution having an acid pH (preferably 4.0 to 5.0) for at least about 10 minutes.

REFERENCES:
patent: 4424206 (1984-01-01), Ohmura et al.
patent: 4721777 (1988-01-01), Uemura et al.
patent: 5190752 (1993-03-01), Moller et al.
Thomas et al., Transfusion (Phila.), vol. 28 (1) pp. 8-13 (1988) (abstract).
Siegel et al., Biochemistry, vol. 20(1) pp. 192-198 (1981) (abstract).
S. Barandun et al, Vox. Sang. 7, 157-174 (1962).
M. Wickerhauser et al, Vox. Sang. 119-125 (1972).

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