Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1982-01-27
1984-03-20
Wiseman, Thomas G.
Drug, bio-affecting and body treating compositions
Lymphokine
435235, 435236, 435239, A61K 3929
Patent
active
044380984
ABSTRACT:
A method of treating the agent of human non-A, non-B hepatitis to render it incapable of causing infection which comprises heating said agent at about 60.degree. C. for about 10 hours and recovering the treated protective agent. Furthermore, this treated agent may be utilized as a vaccine, as, for example, inoculating chimpanzees by i.v. inoculation with the heat treated non-A, non-B agent and the animals have been found protected from later challenge by non-A, non-B hepatitis agent. Thus, the second part of the invention resides in the utilization of a heat-treated agent from human plasma later utilized to protect chimpanzees by incoluation and utilization as a vaccine.
REFERENCES:
patent: 4291020 (1981-09-01), Tabor et al.
Tabor et al., Lancet, pp. 463-466, (Mar. 4, 1978).
Tabor et al., Gastroenterology, vol. 76, No. 4, pp. 680-684, (1979).
Tabor et al., The Journal of Infectious Diseases, vol. 140, No. 5, pp. 789-793, (Nov. 1979).
Shih et al., Hepatology, vol. 2, No. 5, p. 681, (1982).
Tabor et al., The Journal of Infectious Diseases, vol. 142, No. 5, pp. 767-770, (Nov. 1980).
Gerety Robert J.
Tabor Edward
Pepper Frederick W.
Roberts, Jr. John S.
The United States of America as represented by the Secretary of
Wiseman Thomas G.
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