Heat stabilization of plasma proteins

Details Heat stabilization of plasma proteins Heat stabilization of plasma proteins

1982-05-14

1983-04-05

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, C07G 700

Patent

active

043790852

ABSTRACT:
A method for the heat stabilization of a plasma protein such as C1-INA or Factor IX comprising heating the protein in an aqueous medium in the presence of potassium or ammonium citrate in an amount of from in excess of 2.0 M to saturation of the medium. The method is particularly applicable to the stabilization of plasma proteins against thermal denaturation during pasteurization.

REFERENCES:
patent: 2867567 (1959-01-01), Bidwell
patent: 4170590 (1979-10-01), Stephan et al.
Wickerhauser, et al., "Development of Large Scale Fractionation Methods", Vox Sang., 36:281-293, (1979).
Wickerhauser, et al., "Antithrombin III Concentrates for Clinical Use: The Effects of Pasteurization and Freeze Drying", Abs. #35.
Busby, et al., "Thermal Denaturation of Antithrombin III", Journal of Biological Chemistry, vol. 256, No. 23, 12140-12147, (1981).

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