Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-07-04
2006-07-04
Winkler, Ulrike (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S085100, C424S193100, C530S300000, C530S350000, C530S403000
Reexamination Certificate
active
07070785
ABSTRACT:
The present invention relates to the use of heat shock proteins to enhance production of one or more chemokines by a cell. The present invention also relates to the use of a heat shock protein in the treatment or prophylaxis of an infectious disease. The present invention also relates to a peptide from an extracellular domain of CCR5 and the use of the peptide in the treatment or prophylaxis of an infectious disease.
REFERENCES:
patent: WO 97/06821 (1997-02-01), None
patent: WO 97/45543 (1997-12-01), None
patent: WO 97/47319 (1997-12-01), None
patent: WO 98 34641 (1998-08-01), None
Chackerian et al. Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles. Proceedings of the National Academy Science U S A. (1999) vol. 96, No. 5, pp. 2373-2783.
Barrios et al. Mycobacterial heat-shock proteins as carrier molecules. II European Journal of Immunology (1992) vol. 22, p. 1365-1372.
Blond-Elguindi, et al. “Affinity Panning of a Liberty of Peptides Displayed on Bacteriophages Reveals the Binding Specificity of BiP.” Cell, 75, 717-728.
Ciupitu, et al. “Immunization with a Lymphocytic Choriomeningitis Virus Peptide Mixed with Heat Shock protein 70 Results in Protective Antiviral Immunity and Specific Cytotoxic T Lymphocytes.” J. Exp. Med., 187, 685-691, 1998.
Cocchi, et al. “The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection.” Nature Med., 2, 1244-1247, 1996.
Doyle, et al. “Regions Required for CD4 Binding in the External Glycoprotein gp120 of Simian Immunodeficiency Virus.” J. Immunol., 69, 1256-1260, 1995.
Lehner Thomas, et al. “Heat shock proteins generate beta-chemokines which function as innate adjuvants enhancing adaptive immunity.” European Journal of Immunology, vol. 30, No. 2, Feb. 2000, pp. 594-603. XP000985909.
Lehner Thomas, et al. “The role of γδ T cells in generating antiviral factors and beta-chemokines in protection against mucosal simian immunodificiency virus infection.” European Journal of Immunology, vol. 30, No. 8, Aug. 2000, pp. 2245-2256. XP000985908.
Lehner, et al. “Induction of inhibitory antibodies to the CCR5 chemokine receptor and their complementary role in preventing SIV infection in macaques.” Eur. J. Immunol., 29, 2427-2435, 1999.
Lehner, et al. “A rational basis for mucosal vaccination against HIV infection.” Immunological Reviews, 170, 183-196, 1999.
Lehner, et al. “Targeted Lymph Node Immunization with Simian Immunodeficiency Virus p27 Antigen to Elicit Genital, Rectal, and Urinary Immune Responses in Nonhuman Primates.” J. Immunol., 153, 1858-1868, 1994.
Lehner, et al., “Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques.” Nature Medicine, 2, 767-775, 1996.
Lehner, et al. “T- and B-cell functions and epitope expression in nonhuman primates immunized with simian immunodeficiency virus antigen by the rectal route.” PNAS USA, 90, 8638-8642, 1993.
Moriuchi Hiroyuki, et al. “CD8+ T-cell-derived soluble factor(s), but not beta-chemokines RANTES, MIP-1-alpha, and MIP-1-beta, suppress HIV-1 replication in monocyte/macrophages.” Proceedings of the National Academy of Sciences of the United States, vol. 93, No. 26, 1996, pp. 15341-15345. XP002166307.
Nieland, et al. “Isolation of an immunodominant viral peptide that is engogenously bound to the stress protein GP96/GRP94.” PNAS USA, 93, 6135-6139, 1996.
Peng, et al. “Purification of immunogenic heat shock protein 70- peptide complexes by ADP-affinity chromatography.” J. Imm. Methods, 204, 13-21, 1997.
Rucker, et al. “Regions in β-Chemokine Receptors CCR5 and CCR2b That Determine HIV-1 Cofactor Specificity.” Cell, 87, 437-446, 1996.
Simmons, et al. “Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist.” Science, 276, 276-279, 1997.
Suzue K, et al. “Adjuvant-Free HSP70 Fusion Protein System Elicits Humoral and Cellular Immue Repsonse to HIV-1.” Journal of Immunology, US, The William and Wilkins Co. Baltimore, vol. 156, 1996, pp. 873-879. XP002070468.
Thole, et al. “Characterization, Sequence Determination, and Immunogenicity of a 64-Kilodalton Protein ofMycobacterium bovisBCG Expressed inEscherichia coliK-12.” Infect & immune., 55, 1466-1475, 1987.
Udono, et al. “Heat Shock Protein 70-associated Peptides Elicit Specific Cancer Immunity.” J. Exp. Med., 178, 1390-1396, 1993.
Verani Alessia, et al. “C-C chemokines released by lipopolysaccharide (LPS)-stimulated human macrophages suppress HIV-1 infection in both macrophages and T cells.” Journal of Experimental Medicine, vol. 185, No. 5, 1997, pp. 805-816. XP002166304.
Wang Yufei, et al. “Innate function of 70-kD heat shock protein n stimulation of beta-chemokines.” Journal of Human Virology, vol. 3, No. 5, Sep. 2000, p. 243. XP002166305.
Wang, et al. “Generation of CD8 suppressor factor and β chemokines, induced by xenogeneic immunization, in the prevention of simian immunodeficiency virus infection in macaques.” PNAS USA, 95, 5223-5228, 1998.
Yamaguchi H, et al. “Induction of Secretion of Interleukin-8 from Human Gastric Epithelial Cells by Heat-Shock Protein 60 Homologue of Helicobacterpylori.” Journal of Medical Microbiology, Harlow, GB, vol. 48, No. 10, Oct. 1999, pp. 927-933, XP000965601.
Zhu, et al. “Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK.” Science, 272, 1606-1614, 1996.
Zuegel Ulrich, et al. “Immune Response against heat shock proteins in infectious diseases.” Immunobiology, vol. 201, No. 1, Sep. 1999, pp. 22-35. XP000995062.
Mackewicz, C.E., et al. “Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection.” The Lacet, vol. 344, 1671-1673, Dec. 17, 1994.
Mehlert, A., et al. “Biochemical and antigenic characterization of theMycobacterium tuberculosis71kD antigen, a member of the 70kD heat-shock protein family.” Mol. Microbial, 3, 125-130, 1989.
Young, D.B., et al. “Mycobacterial protein antigens: a compilation.” Mol. Microbial., 6, 133-145, 1992.
Kelly Charles George
Lehner Thomas
Wang Yufei
Kohn Kenneth I.
Kohn & Associates PLLC
Winkler Ulrike
LandOfFree
Heat shock proteins for use in enhancing cellular factor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heat shock proteins for use in enhancing cellular factor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heat shock proteins for use in enhancing cellular factor... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3589211