Heat shock protein peptides that share sequences with cyclic nuc

Details Heat shock protein peptides that share sequences with cyclic nuc Heat shock protein peptides that share sequences with cyclic nuc

1994-12-16

1999-02-23

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, A61K 3800

Patent

active

058744053

ABSTRACT:
The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are antigens derived from mycobacterial heat shock proteins and that immunologically crossreact with or are homologous to myelin components. The peptides can also be derived from myelin components such as 2',3' cyclic nucleotide phosphodiesterase and that immunologically crossreact and/or are homologous to mycobacterial heat shock proteins. A method of the invention involves administering a pharmaceutical composition including at least one peptide to an animal in an amount effective to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are useful for the prevention, and treatment of autoimmune inflammatory central nervous system disease.

REFERENCES:
Bernier, et al., Molecular cloning of a 2',3'-cyclic nucleotide 3'-phosphodiesterase, J. Neurosci., vol. 7, No. 9, pp. 2703-2710. Sep. 1987.
Neurology, vol. 44, No. 4, Apr. 1994, pp. A146, Birnbaum G et al.
Clin. Exp. Immunol., vol. 87, No. 1, 1992, pp. 99-104, Yang, X. D. et al.
Human Immunology, vol. 42, Mar. 1995, pp. 301-306, Henwood J. et al.
Springer Semin Immunopathol, vol. 17, No. 1, 1995, Germany, pp. 107-118, Birnbaum G. pp. 114-115.
Neurology, vol. 45, No. 4, Apr. 1995, pp. a226, Birnbaum G. et al.
Journal of Neuroscience Research, vol. 44, No. 4, 15 May 1996, USA pp. 381-396, Birnbaum G. et al.

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