Heat shock protein 90 inhibitors

Details Heat shock protein 90 inhibitors Heat shock protein 90 inhibitors

2007-04-24

2007-04-24

Page, Thurman K. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S163000, C564S169000, C564S171000, C560S009000, C560S011000, C560S019000, C560S051000, C540S484000, C540S544000, C540S479000

Reexamination Certificate

active

10976082

ABSTRACT:
Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol.

REFERENCES:
patent: 6046239 (2000-04-01), Lennox et al.
The Design, Synthesis, and Biological Evaluation of Chimera Based Inhibitors of Hsp90, A Novel Approach to Cancer Chemotherapeutics Poster presentation at Annual Chemical Society meeting in New York on Sep. 8, 2003.

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