Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-25
1998-09-29
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 4352523, 43525411, 435325, 435410, 536 231, C12N 1512, C12N 1563, C12N 100, C12N 510, C12P 2102
Patent
active
058144811
ABSTRACT:
The present invention provides a novel heat shock-like protein (HSPRO) and polynucleotides which identify and encode HSPRO. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of HSPRO.
REFERENCES:
Hightower, L.E., "Heat Shock, Stress Proteins, Chaperones, and Proteotoxicity", Cell, 66: 191-197 (1991).
Marber, M.S. et al., "Overexpression of the Rat Inducible 70-kD Heat Stress Protein in a Transgenic Mouse Increases the Resistance of the Heart to Ischemic Injury", J. Clin. Invest., 95: 1446-1456 (1995).
Simon, M.M. et al., "Heat Shock Protein 70 Overexpression Affects the Response to Ultraviolet Light in Murine Fibroblasts", J. Clin. Invest., 95:926-933 (1995).
Udono, H. et al., "Comparison of Tumor-Specific Immunogenicities of Stress-Induced Proteins gp96, hsp90, and hsp70", J. Immunol., 152: 5398-5403 (1994).
Fang, Y. et al., "Hsp90 Regulates Androgen Receptor Hormone Binding Affinity in Vivo", J. Biol. Chem., 271: 28697-28702 (1996).
Young, R.A., "Stress Proteins and Immunology", Annu. Rev. Immunol., 8: 401-420 (1990).
Sargent, C.A. et al., "Human major histocompatibility complex contains genes for the major heat shock protein HSP70", Proc. Natl. Acad. Sci., 86: 1968-1972 (1989).
Hendrick, J.P. et al., "Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides", Proc. Natl. Acad. Sci., 90: 10216-10220 (1993).
Dix, D.J. et al., "Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility", Proc. Nat. Acad. Sci., 93: 3264-3268 (1996).
Waterson, R., (Direct Submission), GenBank Sequence Database (Accession U80437), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 0703570) Dec. 4, 1996.
Hillman Jennifer L.
Shah Purvi
Billings Lucy J.
Bugalsky Gabriele E.
Incyte Pharmaceuticals Inc.
Wax Robert A.
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