Heat sealable membrane for transdermal drug release

Details Heat sealable membrane for transdermal drug release Heat sealable membrane for transdermal drug release

1988-04-22

1990-08-28

Pellegrino, Stephen C.

Surgery

Truss

Pad

6048901, A61K 900

Patent

active

049516574

ABSTRACT:
A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a release rate controlling membrane, and, a reservoir containing a medicinally active ingredient; the improvement in such system is based on the fact that said membrane is heat and pressure sealed to said backing without the use of a separate adhesive and is formed of a substantially linear block copolymer which is a reaction product of an amino functional polydiorganosiloxane which forms soft segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 50.degree. C. and 200.degree. C. said soft segments comprising from 60 to 90 percent by weight, based on the weight of said copolymer.

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Robert S. Ward, Jr. and Emery Nyilas, Production of Biomedical Polymers I. Silicone/Urethane Synergy in Avcothane.sup.R Elastomers, 1978, p. 224.

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