Heat defibrinogenation of AHF preparation

Details Heat defibrinogenation of AHF preparation Heat defibrinogenation of AHF preparation

1984-02-09

1984-12-04

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

260112R, A61K 3516

Patent

active

044864108

ABSTRACT:
Antihemophilic factor (AHF), a blood component necessary for clotting of normal whole blood, is extracted from cryoprecipitate containing AHF and fibrinogen as its principal components by: rapidly raising and thereafter lowering the temperature of the cryoprecipitate suspension to selectively denature the fibrinogen in the suspension; and separating the AHF-rich supernatant from the denatured fibrinogen.

REFERENCES:
patent: 4085095 (1978-04-01), Bick et al.
patent: 4170639 (1979-10-01), Liu et al.
patent: 4188318 (1980-02-01), Shanbrom

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