Heart rejection monitoring apparatus and method

Surgery – Truss – Pad

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128696, A61N 108

Patent

active

051390280

ABSTRACT:
An implantable cardiac allograft rejection monitoring apparatus and method for measuring stimulated intracardiac electrogram potentials, performing processing and time based analysis of changes in the potential, and deriving from the time history of the analyzed signals allograft rejection control parameters. The apparatus communicates the allograft rejection control parameters to an external communicating device and may use the parameters to control the output of an implanted drug infusion pump.

REFERENCES:
patent: 4531936 (1985-07-01), Gordon
patent: 4692719 (1987-09-01), Whigham
patent: 4821724 (1989-04-01), Whigham et al.
A. Keren et al., "Heart Transplant Rejection Monitored By Signal-Averaged Electrocardiography in Patients Receiving Cyclosporine," Circulation, vol. 70 (Suppl I), pp. I-124 through I-128 (Sep. 1984).
H. Warnecke et al., "Noninvasive Monitoring of Cardiac Allograft Rejection By Intramyocardial Electrogram Recordings," Circulation, vol. 74 (Suppl. III), pp. III-72 through III-76 (Nov. 1986).
R. Haberl et al., "Frequency Analysis of the Surface Electrocardiogram for Recognition of Acute Rejection After Orthotopic Cardiac Transplantation in Man," Circulation, vol. 76, No. 1, pp. 101-108 (Jul. 1987).
A. A. Grace et al., "Assessment of Intracardiac T Wave Amplitude Measurement in Predicting Cardiac Allograft Rejection," PACE, vol. 13, pp. 542, Abstract No. 180 (Apr. 1990).

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