Heart preservation and transportation apparatus and method emplo

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems

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435283, A61N 1362, A01N 102

Patent

active

057163782

ABSTRACT:
A system and method for preservation and transport of a donor heart are provided, which includes features for improving the refreshment of the myocardium and for removing toxic catabolites, thereby lengthening the available time for effective transport. The invention utilizes a housing with a perfusion subsystem for retrogradely perfusing the heart, and a subsystem for maintaining the heart in a moderate hypothermic state, preferably at about 10-25 C. A pacemaker is utilized to pace the heart at a below normal rate, preferably in the range of 2-40 bpm, and more preferably 15-30 bpm, so as to continuously squeeze out catabolites and refresh the myocardium with the perfusion fluid. The system can be portable, where the heart can be maintained with or without dialysis; when the apparatus is not being transported, it utilizes power line energy and is adapted to provide dialysis.

REFERENCES:
patent: 5051352 (1991-09-01), Martindale et al.
patent: 5338662 (1994-08-01), Sadri
patent: 5356771 (1994-10-01), O'Dell
patent: 5391142 (1995-02-01), Sites et al.
"Pathophysiologic of features of biological preservation of the heart using
"Evaluation of the functional state of the heart transplant 20-24 hours (USSR) Mar.-Apr. 1988, 34 (2) pp. 51-56, ISSN -0201-8489, EWR, Barinov EF
"Isolated working rat heart perfusion with perfluorochemical emulsion 1982.
"Prolonged support of working rabit hearts using Fluosol-43 or erythrocyte
"Fluorochemical emulsion APE-LM substantially improves cardiac 1992.
"Long term heart preservation by intermittent perfusion with crystalloid
"Importance of Substrate Enhancement for Long-term Heart Preservation",
"Posttransplantation Function of Hearts Preserved with Fluorochemical

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