Heart homing conjugates

Details Heart homing conjugates Heart homing conjugates

2006-12-05

2006-12-05

Campbell, Bruce (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07144860

ABSTRACT:
The present invention provides a heart homing peptide that contains the amino acid sequence GGGVFWQ (SEQ ID NO: 2); HGRVRPH (SEQ ID NO: 3); VVLVTSS (SEQ ID NO: 4); CLHRGNSC (SEQ ID NO: 9); or CRSWNKADNRSC (SEQ ID NO: 10) and further provides conjugates in which a heart homing peptide is linked to a moiety such as a therapeutic agent. The conjugates of the invention are useful for treating cardiovascular diseases such as atherosclerosis and restenosis.

REFERENCES:
patent: 5622699 (1997-04-01), Ruoslahti et al.
patent: WO 97/10507 (1997-03-01), None
Billups et al., “Expression of E-selection mRNA during ischemia/reperfusion injury,”J. Lab. Clin. Med.125:626-633 (1995).
Bowles et al., “Prospects for adenovirus-mediated gene therapy of inherited diseases of the myocardium,”Cardiovascular Research35:422-430 (1997).
Giordano et al., “Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart,”Nature Medicine2:534-539 (1996).
Harada et al., “Vascular endothelial growth factor administration in chronic myocardial ischemia,”American Journal of Physiol.270:H1791-H1802 (1996).
Herskowitz et al., “Cytokine mRNA Expression in Postischemic/Reperfused Myocardium,”Am. J. Pathol.146:419-428 (1995).
Indolfi and Chiariello, “Gene therapy for cardiovascular disorders,”Cardiologia43:365-373 (1998).
Isner et al., “Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165in patient with ischemic limb,”The Lancet348:370-374 (1996).
Knight and Fox, “The Vicious Circle of Ischemic Left Ventricular Dysfunction,”Am. J. Cardiol.75:10E-15E (1995).
Korthuis et al., “Role of Neutrophil-Endothelial cell Adhesion in Inflammatory Disorders,”J. Crit. Care9(1):47-71 (1994).
Kukielka et al., “Role of early reperfusion in the induction of adhesion molecules and cytokines in previously ischemic myocardium,”Molec. And Cell Biochem.147:5-12 (1995).
Lefer and Lefer, “Pharmacology of the Endothelium in Ischemia-Reperfusion and Circulatory Shock,”Annu. Rev. Pharmacol. Toxicol.33:71-90 (1993).
Ma et al., “Coronary Endothelial and Cardiac Protective Effects of a Monoclonal Antibody to Intercellular Adhesion Molecule-1 in Myocardial Ischemia and Reperfusion,”Circulation86:937-946 (1992).
Marche et al., “Pharmacologic treatment of atherosclerosis: beyond lipid-lowering therapy,”International Journal of Cardiology62:S17-S22 (1997).
Meredith et al., “Role of Endothelium in Ischemic Coronary Syndromes,”Am. J. Cardiol.72:27C-32C (1993).
Pasqualini and Ruoslahti, “Organ targeting in vivo using phage display peptide libraries,”Nature380:364-366 (1996).
Rader, “Gene therapy for atherosclerosis,”Int. J. Clin. Lab. Res.27:35-43 (1997).
Rajotte et al., “Molecular Heterogeneity of the Vascular Endothelium Revealed by in Vivo Phage Display,”J. Clin. Invest.102:430-437 (1998).
Scalia et al., “Myocardial protection by N,N,N-trimethylsphingosine in ischemia reperfusion injury is mediated by inhibition of P-selectin,”J. Leukoc. Biol.59:317-324 (1996).
Schachter, “Calcium antagonists and atherosclerosis,”International Journal of Cardiology62:S9-S15 (1997).
Schachter, “Vascular smooth muscle cell migration, atherosclerosis, and calcium channel blockers,”International Journal of Cardiology62:S85-S90 (1997).
Seccombe and Schaff, “Coronary Artery Endothelial Function After Myocardial Ischemia and Reperfusion,”Ann. Thorac. Surg.60:778-788 (1995).
Simari and Nabel, “Genetic Therapy,”Semin. Intervent. Cardiol.1:77-83 (1996).
Trost et al., “Protection Against Myocardial Dysfunction After a Brief Ischemic Period in Transgenic Mice Expressing Inducible Heat Shock Protein 70,”J. Clin. Invest.101:855-862 (1998).
Weyrich et al., “Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium,”J. Leukoc. Biol.57:45-55 (1995).
Youker et al., “Molecular Evidence for Induction of Intracellular Adhesion Molecule-1 in the Viable border Zone Associated with Ischemia-Reperfusion Injury of the Dog Heart,”Circulation89:2736-2746 (1994).

Affiliated with

Also associated with

Rating

Heart homing conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heart homing conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heart homing conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3685685