Chemistry: molecular biology and microbiology – Apparatus – Differentiated tissue perfusion or preservation apparatus
Patent
1996-07-26
1998-09-15
Beisner, William H.
Chemistry: molecular biology and microbiology
Apparatus
Differentiated tissue perfusion or preservation apparatus
435 12, 4352865, 4352866, A01N 102
Patent
active
058077375
ABSTRACT:
A heart and lung support assembly for extracorporeal support of a heart and one or both associated lungs, using the lungs of the donor as oxygenators. The heart and lung support assembly is controlled by an automated feedback control system to monitor and control various attributes of the heart, lungs, and blood, such that the heart and lungs may be stabilized for an extended period of time in an extracorporeal state. The heart and lung support assembly includes generally a housing, a chest cavity actuator assembly, a blood pressure controller assembly, and an automated monitor and feedback control system. The housing is provided for receiving the heart, lungs, and trachea after being removed from the donor patient as a unit. The chest cavity actuator assembly is carried on the exterior of the housing and is provided for simulating normal inhaling and exhaling by the donor lungs. The blood pressure controller assembly is carried by the housing and includes a fluid circuit for the circulation of blood through the heart and lungs to simulate the normal circulation of blood and to provide a means for monitoring the composition and controlling the flow of the blood. The automated monitor and feedback control system includes an arterial cell for detecting at least the partial pressure of oxygen, the partial pressure of carbon dioxide, and pH levels in blood as the blood passes therethrough. A plurality of blood pressure detectors is provided for measuring the various pressures of interest.
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Chien et al"A simple technique for multiorgan preservation." J. Thorac. Cardiovasc. Surg. vol. 95 (1988), pp. 55-61.
Schill David M.
Schill Joseph G.
Schill, Jr. Robert A.
Beisner William H.
Schill Enterprises, Inc.
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