Healing composition employing an enzyme-modified casein

Details Healing composition employing an enzyme-modified casein Healing composition employing an enzyme-modified casein

1989-03-23

1992-11-24

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 424DIG13, 530360, 530361, 530832, 530833, A61K 3716

Patent

active

051661322

ABSTRACT:
A topical use pharmaceutical composition and a process for its preparation, comprising an improved enzyme-modified casein sol. Prior to being enzyme-modified, the casein is solubilized and neutralized by an alkali solution containing a molar weight percent ratio in the range of from 90:10 to 100:0, potassium hydroxide to sodium hydroxide. Said neutralization occurring for a time in the range of 5 to 35 minutes to allow for complete neutralization of the casein. The neutralized casein is then hydrolyzed or modified by enzymatic digestion by a proteolytic enzyme for a time sufficient to achieve a weight ratio of protein nitrogen to amino nitrogen in the range from 7:1 to 9:1. The improved enzyme-modified casein sol may then be mixed with stabilizing and pressuring agents, such as carrageenan, polyvinyl pyrrolidone, methyl paraben or propyl paraben. Topical uses for the improved enzyme-modified casein composition include healing and relieving infections, wounds, burns, dermatitis, skin eruptions, dandruff, hemorrhoids and bruises.

REFERENCES:
patent: 3558770 (1971-01-01), Gordon et al.
Scopes, Protein Purification, 1982, Springer-Verlag, New York, pp. 40-42.
Forbes, Beyond the Band-Aid, Jun. 1, 1987, Science & Technology.

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