Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-01-20
1999-11-09
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 71, 435 72, 4352523, 4353201, 530350, 536 235, 536 243, C07K 14705, C12N 1512, G01N 3353
Patent
active
059812230
ABSTRACT:
HDPXU17 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HDPXU17 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
REFERENCES:
Human Genome Sciences Corporation (HGS) EST#2295303.
Ayyanathan, K., et al. "Cloning and Chromosomal Localization of the Human P2Y1 Purinoceptor" Biochemical and Biophysical Res. Commun. 218(3): 783-788 (1996).
Takeda, J., et al., "A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones" Human. Molecular. Genetics:2(11), 1793-1798 (1993).
GenBank Accession #AF030335.
GenBank Accession #Z49205.
GenBank Accession #T10449.
GenBank Accession#AA405284.
George et al. publication Macromolecular Sequencing and Synthesis, Selected Methods and Applications, Alan R. Liss, Inc., chptr. 12, pp. 127-149, 1988.
Webb et al. Cloning and Functional Expression of a Brain G-protein-coupled ATP Receptor. FEBS Letters 324(2):219-225, Sep. 1993.
Bergsma Derk J
Halsey Wendy S
Sathe Ganesh M
Hecht Elizabeth J.
King William T.
SmithKline Beecham Corporation
Ulm John
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