Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2010-04-23
2011-11-15
Nashed, Nashaat (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S324000, C530S344000
Reexamination Certificate
active
08058390
ABSTRACT:
The present invention includes crystallized HDM2 peptides as well as descriptions of the X-ray diffraction patterns of the crystals. The diffraction patterns allow the three dimensional structure of HDM2 to be determined at atomic resolution so that ligand binding sites on HDM2 can be identified and the interactions of ligands with HDM2 amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MDM2 and HDM2 oncoproteins.
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Deckman Ingrid
Grasberger Bruce
Maguire Diane
Schubert Carsten
Spurlino John
Nashed Nashaat
Ortho-McNeil Pharmaceutical , Inc.
Shah Rajiv S.
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