HDL for the treatment of stroke and other ischemic conditions

Details HDL for the treatment of stroke and other ischemic conditions HDL for the treatment of stroke and other ischemic conditions

2007-05-04

2009-02-17

Saidha, Tekchand (Department: 1652)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S359000

Reexamination Certificate

active

07491693

ABSTRACT:
The present invention relates to a method for the prophylaxis and/or treatment of stroke and other ischemic injury, wherein HDL is administered to a subject in need thereof, particularly by intravenous infusion.

REFERENCES:
patent: 5780592 (1998-07-01), Mullner et al.
patent: WO 01/03705 (2001-01-01), None
patent: WO 01/13939 (2001-03-01), None
patent: WO 01/38395 (2001-05-01), None
Excerpt from MacQuarie Australia's National Dictionary; 2 pages, 1998.
Excerpt from Stedman's Medical Dictionary; pp. 924, 2000.
Excerpt from Black's Medical Dictionary; pp. 497, 1984.
Excerpt from Gould Medical Dictionary; pp. 798, 1972.
Orekhov, A.N. et al.; “Artificial HDL as an anti-atherosclerotic drug;” The Lancet; Nov. 17, 1984; pp. 1149-1150.
Dansky, Hayes M. et al.; “High-Density Lipoprotein and Plaque Regression: The Good Cholesterol Gets Even Better;” Circulation, Journal of the American Heart Association; 1999; vol. 100; pp. 1762-1763.
Badimon, J.J. et al.; “Regression of Atherosclerotic Lesions by High Density Lipoprotein Plasma Fraction in the Cholesterol-fed Rabbit;” Journal of Clinical Investigation; Apr. 1990; vol. 85; pp. 1234-1241.
Cockerill et al. “High-density lipoproteins rescue end-stage organ failure in a rat model of haemorraghic shock,”J. Submicroscopic Cyt. Path. 32(3): 353, 2000.
Klimov, et al., “Effect of high density lipoproteins on permeability of rabbit aorta to low density lipoproteins,”Atherosclerosis, 1985, 55(2):217-23.
Lerch, et al., “Reconstituted high density lipoprotein (rHDL) modulates platelet activity in vitro and ex vivo,”Thromb Haemost. 1998, 80(2):316-20.

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