HDAC9 polypeptides and polynucleotides and uses thereof

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300, C435S320100, C536S023100, C424S094600

Reexamination Certificate

active

07063973

ABSTRACT:
The present invention features substantially pure HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), an HDRP(ΔNLS) polypeptides, and isolated nucleic acid molecules encoding those polypeptides. The present invention also features vectors containing HDAC9, HDAC9a, HDAC9(ΔNLS), HDAC9a(ΔNLS), and HDRP(ΔNLS) nucleic acid sequences, and cells containing those vectors.

REFERENCES:
patent: 5659016 (1997-08-01), Nakamura et al.
patent: 5763182 (1998-06-01), Nakamura et al.
patent: 6287843 (2001-09-01), Baldwin et al.
patent: 2001/0010909 (2001-08-01), Cahoon et al.
patent: 2001/0012836 (2001-08-01), Hu et al.
patent: WO 97/35990 (1997-10-01), None
patent: WO 00/10583 (2000-03-01), None
patent: WO 01/18045 (2001-03-01), None
patent: WO 01/18171 (2001-03-01), None
patent: WO 01/42437 (2001-06-01), None
patent: WO 02/36783 (2002-05-01), None
patent: WO 02/102323 (2002-12-01), None
Nagase, T., et al., “Prediction of the Coding Sequences of Unidentified Human Genes. XI. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro,”DNA Research,5: 277-286 (1998).
Buggy, J.J., et al., “Cloning and Characterization of a Novel Human Histone Deacetylase, HDAC8,”Biochem. J.,350:199-205, (2000).
Cress, W.D., and Seto, E., “Histone Deacetylases, Transcriptional Control, and Cancer,”Journal of Cellular Physiology, 184:1-16, (2000).
Dangond, F., et al., “Differential Display Cloning of a Novel Human Histone Deacetylase (HDAC3) cDNA from PHA-activated Immune Cells,”Biochem. Biophys. Res. Commun.,242(3):648-652, (1998).
Emiliani, S., et al., “Characterization of a human RPD3 ortholog, HDAC3,”Proc. Natl. Acad. Sci. USA,95:2795-2800, (1998).
Fischle, W., et al., “A New Family of Human Histone Deacetylases Related toSaccharomyces cerevisiaeHDA1p,”The Journal of Biological Chemistry,274(17):11713-11720, (1999).
Grozinger, C.M., et al., “Three Proteins Define a Class of Human Histone Deacetylases related to Yeast Hda1p,”Proc. Natl. Acad. Sci. USA,96:4868-4873, (1999).
Hu, E., et al., “Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor”The Journal of Biological Chemistry,275(20):15254-15264 (2000).
Marks, P.A., et al., “Histone Deacetylase Inhbitors as New Cancer Drugs,”Curr. Opin. Oncol.,13:477-483, (2001).
Marks, P., et al., “Histone Deacetylases and Cancer: Causes and Therapies,”Nat. Rev. Cancer.,1:194-202, (2001).
Miska, E.A., et al., “HDAC4 Deacetylase Associates With and Represses the MEF2 Transcription Factor,”The EMBO Journal,18:5099-5107, (1999).
Richon, et al.,“A Class of Hybrid Polar Inducers of Transformed Cell Differentiation Inhibits Histone Deacetylases,”Proc. Natl. Acad. Sci. USA,95:3003-3007 (1998).
Sparrow, D.B., et al., “MEF-2 Function is Modified by a Novel Co-repressor, MITR,”The EMBO Journal,18:5085-5098, (1999).
Van den Wyngaert, I., et al., “Cloning and Characterization of Human Histone Deacetylases 8,”FEBS Lett.,478:77-83, (2000).
Wang, A.H., et al., “HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor,”Molecular and Cellular Biology,19:7816-7827, (1999).
Yang, X-J., et al., “A p300/CBP-associated Factor that Competes With the Adenoviral Oncoprotein E1A,”Nature,382:319-324, (1996).
Yang, W-M., et al., “Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family,”The Journal of Biological Chemistry,272:28001-28007, (1997).
Zhang, C.L., et al., “The Transcriptional Corepressor MITR is a Signal-responsive Inhibitor of Myogenesis,”Proc. Natl. Acad. Sci. USA,98:7354-7359, (2001).
Zhang, C.L., et al., “Association of COOH-terminal-binding Protein (CtBP) and MEF2-interacting Transcription Repressor (MITR) Contributes to Transcriptional Repression of the MEF2 Transcription Factor,”The Journal of Biological Chemistry,276:35-39, (2001).
Zhou, X., et al., “Identification of a Transcriptional Repressor Related to the Noncatalytic Domain of Histone Deacetylases 4 and 5,”Proc. Natl. Acad. Sci. USA,97:1056-1061, (2000).
Zhou, X., et al., “Cloning and Characterization cf a Histone Deacetylase, HDAC9,”PNAS,98:10572-10577, (2001).
Wang, AH et al., 1999, “HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor,”Mol. Cell Biol.19: 7816-7827.
Hedge, et al. (2000) “EST380989 MAGE Resequences, MAGJ Homo sapiens cDNA, mRNA Sequence”, Database EMBL Acc. No.: AW968913, Abstract.
Macleod, et al. (2000) “Human Histone Deacetylase HDAC-5 Coding Sequence”, Database EMBL Acc. No. AAC89558, Abstract.
Macleod, et al. (2001) “Human Histone Deacetylase HDAC-4 Coding Sequence”, Database EMBL Acc. No. AAC89557, Abstract.
Zhang, et al. (2001) “Mus Musculus MEF2-Interacting Transcription Repressor MITR (Mitr) mRNA, Comp. cds”, Database EMBLAcc. No. AF324492, Abstract.
Zhou et al. (2001) “Mus Musculus Histone Deacetylase Related Protein mRNA”, Database EMBL Acc. No. AF235053, Abstract.
Copy of European Search Report dated Sep. 20, 2005.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

HDAC9 polypeptides and polynucleotides and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HDAC9 polypeptides and polynucleotides and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HDAC9 polypeptides and polynucleotides and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3669198

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.