Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-09
2008-12-16
Habte, Kahsay T (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252050, C514S255050, C514S256000
Reexamination Certificate
active
07465731
ABSTRACT:
A compound having the formula (I):whereinR1is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl, cyclo(higher)alkyl(lower)alkyl, cyclo(lower)alkenyl(lower)alkyl, aryl-fused cyclo(lower)alkyl, lower alkoxy, acyl, aryl, ar(lower)alkoxy, ar(lower)alkyl, heteroar(lower)alkyl, amino, heteroaryl, heterocyclyl or heterocyclyl(lower)alkyl, which may be substituted with one or more suitable substituent(s),R2is hydrogen or lower alkyl,X is arylene, heterorarylene, cycloalkylene, heterocycloalkylene or aryl-fused cycloalkene,Y is arylene, heteroarylene, which may be substituted with one or more suitable substituent(s),Z lower alenylene, which may be substituted with lower alkyl or halogen,or a salt thereof. The compound is useful as a histone deacetylase inhibitor.
REFERENCES:
patent: 7135493 (2006-11-01), Urano et al.
patent: 2006/0052599 (2006-03-01), Ishibashi et al.
Eikyu Yoshiteru
Inoue Yoshikazu
Ishibashi Naoki
Kamijo Kazunori
Mukoyoshi Koichiro
Astellas Pharma Inc.
Habte Kahsay T
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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