HCV NS3 protease inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S009100, C514S018700, C514S019300, C530S331000, C540S455000

Reexamination Certificate

active

07470664

ABSTRACT:
The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

REFERENCES:
patent: 2004/0229776 (2004-11-01), Chen et al.
patent: 2004/0229818 (2004-11-01), Llinas-Brunet et al.
patent: 2005/0020503 (2005-01-01), Llinas-Brunet et al.
B. W. Dymock, “Novel Approaches to the Treatment of Hepatitis C Virus Infection”, 2000, pp. 79-86, vol. 11, Antiviral Chemistry & Chemotherapy.
H. R. Rosen et al., “Hepatitis C Virus: Current Understanding and Prospects for Future Therapies”, 1999, pp. 393-399, vol. 5, Molecular Medicine Today.
D. Moradpour et al., “Current and Evolving Therapies for Hepatitis C”, 1999, European J. Gastroenterol. Hepatol.
R. Bartenschlager, “Candidate Targets for Hepatitis C Virus-Specific Antiviral therapy”, 1997, pp. 378-393, vol. 40, N. Engl. Intervirology.
G. M. Lauer et al., “Hepatitis C Virus Infection”, 2001, pp. 41-52, vol. 345, J. Med.
B. W. Dymock, “Emerging Therapies for Hepatitis C Virus Infection”, 2001, pp. 13-42, vol. 6, Emerging Drugs.
C. Crabb, “Hard-Won Advances Spark Excitement about Hepatitis C”, 2001, pp. 506-507, Science.

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