Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2006-07-18
2006-07-18
Nashed, Nashaat T. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S023000, C435S069100, C435S069700, C435S252300, C536S023200, C536S023720
Reexamination Certificate
active
07078215
ABSTRACT:
Truncated HCV NS2/3 can be produced recombinantly and renatured into functional enzyme, useful in assays for modulators of activity and HCV function.
REFERENCES:
patent: 5837464 (1998-11-01), Capon et al.
patent: 5888762 (1999-03-01), Joliot et al.
patent: 6197536 (2001-03-01), Steinkuhler et al.
patent: 6242187 (2001-06-01), Capon et al.
patent: 6280940 (2001-08-01), Potts et al.
patent: 6599738 (2003-07-01), Potts et al.
patent: 6790612 (2004-09-01), Potts et al.
patent: 6815159 (2004-11-01), Thibeault et al.
patent: WO 97/08304 (1997-03-01), None
patent: WO 2001/16379 (2001-03-01), None
Belyaev, A. et al. “Hepatitis G Virus Encodes Protease Activities Which Can Effect Processing of the Virus Putative Nonstructural Proteins”, Journal of Virology, 1998, vol. 72, pp. 868-872.
Darke, P. et al. “Inhibition of Hepatitis C Virus NS2/3 Processing by NS4A Peptides”, The Journal of Biological Chemistry, 1999, vol. 274, pp. 34511-34514.
Grakoui, A. et al. “A second hepatitis C virus-encoded proteinase”, Proc. Natl. Acad. Sci. USA, 1993, vol. 90, pp. 10583-10587.
Han, D .et al. “Identification of the protease domain in NS3 of hepatitis C virus”, Journal of General Virology, 1995, vol. 76, pp. 985-993.
Han, J. et al. “Group specific sequences and conserved secondary structures at the 340 end of HCV genome and is implication for viral replication”, Nucleic Acids Research, 1992, vol. 20, pp. 3520.
Hijikata, M. et al. “Two Distinct Proteinase Activities Required for the Processing of a Putative Nonstructural Precursor Protein of Hepatitis C Virus”, Journal of Virology, 1993, vol. 67, pp. 4665-4675.
Hotta, H. et al. “Analysis of the core and E1 envelope region sequences of a novel variant of hepatitis c virus obtained in Indonesia”, Archives of Virology, 1994, vol. 136, pp. 53-62.
Inchauspe, G. et al. “Genomic structure of the human prototype strain H of hepatitis C virus: Comparison with American and Japanese isolates”, Proc. Natl. Acad. Sci. USA, 1991, vol. 88, p. 10292-10296.
Kato, N. et al. “A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection”, Jpn. J. Cancer Res., 1990, vol. 81, pp. 1092-1094.
Kato, N. et al. “Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis”, Proc. Natl. Acad. Sci. USA, 1990, vol. 87, pp. 9524-9528.
Kato, N. et al. “Molecular structure of the Japanese hepatitis C viral genome”, FEBS Letters, 1991, vol. 280, pp. 325-328.
Kim, J. et al. “Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding”, Strucure, 1998, vol. 6, pp. 89-100.
Kolykhalov, A. et al. “Hepatitis C Virus-Encoded Enzymatic Activities and Conserved RNA Elements in the 3′ Nontranslated Region Are Essential for Virus Replication In Vivo”, Journal of Virology, 2000, vol. 74, pp. 2046-2051.
Kolykhalov, A. et al. “Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA”, Science, 1997, vol. 277, pp. 570-574.
Mink, M. et al. “Characterization and Mapping of a B-Cell Immunogenic Domain in Hepatitis C Virus E2 Glycoprotein Using a Yeast Peptide Library”, Virology, 1994, vol. 200, pp. 246-255.
Miyakawa, Y. et al. “Classifying hepatitis C virus genotypes”, Molecular Medicine Today, 1995, vol. 1, pp. 20-25.
Pallaoro, M. et al. “Characterization of the Hepatitis C Virus NS2/3 Processing Reaction by Using a Purified Precursor Protein”, Journal of Virology, 2001, vol. 75, pp. 9939-9946.
Pieroni, L. et al. “In Vitro Study of the NS2-3 Protease of Hepatitis C Virus”, Journal of Virology, 1997, vol. 71, pp. 6373-6380.
Reed, K. et al. “Hepatitis C Virus-Encoded NS2-3 Protease: Cleavage-Site Mutagenesis and Requirements for Bimolecular Cleavage”, Journal of Virology, 1995, vol. 69, pp. 4127-4136.
Santolini, E. et al. “The NS2 Protein of Hepatitis C Virus Is a Transmembrane Polypeptide”, Journal of Virology, 1995, vol. 69, pp. 7461-7471.
Tokita, H. et al. “Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2e and 2f), tenth (10a) and eleventh (11a) genetic groups”, Journal of General Virology, 1996, vol. 77, pp. 293-301.
Wilkinson, C. “Hepatitis C virus NS2-3 proteinase”, Biochemical Society Transactions, 1997, vol. 25, pp. S611.
Wu, Z. et al. “Mechanism of autoproteolysis at the NS2-NS3 junction of the hepatitis C virus polyprotein”, TIBS, 1998, vol. 23, pp. 92-94.
Yao, N. et al. “Structure of the hepatitis C virus RNA helicase domain”, Nature Structural Biology, 1997, vol. 4, pp. 463-467.
Lahm Armin
Pallaoro Michele
Steinkuhler Christian
Heber Sheldon O.
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti, S.P.A.
Moore William W.
Nashed Nashaat T.
Tribble Jack L.
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