Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-01-03
2010-11-23
Lucas, Zachariah (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S185100, C435S007100, C436S820000
Reexamination Certificate
active
07838002
ABSTRACT:
The present invention relates to a novel form of core+1 protein of Hepatitis C virus (HCV), designated shorter form core+1 protein. The shorter form core+1 protein of Hepatitis C virus is the product of translation of a coding sequence consisting of all or part of a nucleotide sequence extending from nucleotide 598 to nucleotide 920 within the core+1 ORF of HCV represented on FIG.3B. The invention also provides methods for detecting infection by Hepatitis C virus in biological samples, methods of screening compounds which interact with viral propagation in HCV infected cells or screening of compounds impaction on the expression of shorter form core+1 protein and uses of these compounds for the preparation of compositions useful for their anti-viral activities.
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Reynolds et al (1995) EMBO Journal. 14(23): 6010-6020.
Varaklioti, et al., “Alternate Translation Occurs Within the Core Coding Region of the Hepatitis C Viral Genome”, Journal of Biological Chemistry, vol. 277, No. 20, XP002274109, ISSN: 0021-9258, pp. 17713-17721, (May 17, 2002).
Xu, et al., “Synthesis of a Novel Hepatitis C Virus Protein by Ribosomal Frameshift”, EMBO Journal, Oxford University Press, Surrey, GB, vol. 20, No. 14, XP002246932, ISSN: 0261-4189, pp. 3840-3848, (Apr. 2001).
Walewski, et al., “Evidence for a New Hepatitis C Virus Antigen Encoded in an Overlapping Reading Frame”, RNA New York, vol. 7, No. 5, XP002274110, ISSN: 1355-8382, pp. 710-721, (May 2001).
Vassilaki, et al., “Two Alternative Translation Mechanisms Are Responsible for the Expression of the HCV ARFP/F/Core+1 Coding Open Reading Frame”, Journal of Biological Chemistry, vol. 278, No. 42, XP002274111, ISSN: 0021-9258, pp. 40503-40513, (Oct. 17, 2003).
Mavromara Penelope
Vassilaki Niki
Finnegan Henderson Farabow Garrett & Dunner LLP
Horning Michelle
Institut Pasteur
Institut Pasteur Hellenique
Lucas Zachariah
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