HCV/BVDV chimeric genomes and uses thereof

Details HCV/BVDV chimeric genomes and uses thereof HCV/BVDV chimeric genomes and uses thereof

2006-03-07

2006-03-07

Housel, James C. (Department: 1648)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S023700, C435S235100, C435S239000, C435S069100, C435S320100

Reexamination Certificate

active

07009044

ABSTRACT:
The present invention relates to molecular approaches to the production of nucleic acid sequences which comprise the genomes of chimeric hepatitis C virus-bovine viral diarrhea viruses (HCV/BVDV). The invention also relates to the use of these chimeric nucleic acid sequences to produce chimeric virions in cells and the use of these chimeric virions in HCV antibody neutralization assays, and for the development of vaccines and therapeutics for HCV.

REFERENCES:
patent: 6326137 (2001-12-01), Hong et al.
patent: WO 96/04385 (1996-02-01), None
patent: WO 98/37911 (1998-09-01), None
patent: WO 99/55366 (1999-11-01), None
Nam et al., Journal of Virological Methods, vol. 97 No. 1-2, pp. 113-123 (Sep. 2001).
Vassilev et al., Journal of Virology, vol. 71 No. 1, pp. 471-478 (Jan. 1997).
Kashiwakuma et al., Journal of Immunological Methods, vol. 190 No. 1, pp. 79-89 (Mar. 1996).
Frolov, I et al, “Cis-Acting RNA Elements Required for Replication of Bovine Viral Diarrhea Virus-Hepatitius C Virus 5′ Non-translated Region Chimeras” RNA, Cambridge University Press, Cambridge, GB 4:11 (pp. 1418-1435) Nov. 1998.
Lu, H. et al, “Poliovirus chimeras replicating under the translation control of genetic elements of HCV reveal unusual properties of the IRES of HCV” PNAS, NAS 93 (pp. 1412-1417) Feb. 1996.
Venugopal, K. and Gould, E.A., “Towards a new generation of Flavivirus Vaccines” Vaccine 2:11 (pp. 966-975) 1994.
Meyers, G. et al, “Recovery of Cytopathogenic and Non-Cytopathogenic Bovine Viral Diarrhea Viruses from cDNA Constructs” Journal of Virology, The AMerican Society for Microbiology 70:12 (pp. 8606-8613) Dec. 1996.
Yu, H. et al, “Sequence and Structural Elements at the 3′ Terminus of Bovine Viraldiarrhea Virus Genomic RNA: Functional Role During RNA Replication” Journal of Virology, The American Society for Microbiology 73:5 (pp. 3638-3648) May 1999.
Lai, VC; Zhong, W.; Skelton, A.; Ingravallo, P.; Vassilev, V.; Donis, RO.; Hong, Z.; and Lau JY, “Generation and characterization of a hepatitis C virus NS3 protease-dependent bovine viral diarrhea virus.” Journal of Virology 74:14 (pp. 6339-6347) Jul. 2000.

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