HCMV/HSV fusion glycoproteins

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

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435 693, 435 691, 435 697, 4241851, 4241921, 4242301, C12P 2106, C12P 2102, C07K 100, A61K 39245

Patent

active

057392927

ABSTRACT:
A fusion protein comprising a portion of a glycoprotein of HCMV fused to a portion of a glycoprotein of HSV is described.

REFERENCES:
Flexner, et al., "Successful vaccination with a polyvalent live vector despite existing immunity to an expressed antigen", Nature, 335, No. 6781, pp. 259-262 (1988).
Cranage, et al., "Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus", The Embo Journal, 5, No. 11, pp. 3057-3063 (1986).
Forrester, et al., "Construction and Properties of a Mutant of Herpes Simplex Virus Type 1 with Glycoprotein H Coding sequences Deleted", J. Virol., 66, No. 1, pp. 341-348 (1992).
Britt et al., J. Infect. Dis., 171:18-25, 1995.
Curtsinger et al., J. Gen. Virol., 75:301-307, 1994.

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