HCMV/HSV fusion glycoproteins

Details HCMV/HSV fusion glycoproteins HCMV/HSV fusion glycoproteins

1997-12-23

2000-03-14

Wortman, Donna C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Combination of antigens from multiple viral species

4241851, 4241841, 4241921, 4242301, 4241861, 530395, 435 693, 435 691, 435 697, 536 235, A61K 3900, A61K 39245, C12P 2106, C07K 100

Patent

active

060369590

ABSTRACT:
A fusion protein comprising a portion of a glycoprotein of HCMV fused to a portion of a glycoprotein of HSV is described.

REFERENCES:
patent: 5739292 (1998-04-01), Gheysen
Aurelian L., "Herpes Simplex Viruses", In: Encyclopedia of Virology, vol. 2, Webster & Granoff, A., eds., Academic Press, New York, pp. 587-593, 1994.
Cranage et al. The EMBO Journal 5(11): 3057-3063, 1986.
Britt et al. Journal of Infectious Diseases 171:18-25, 1995.
Curtsinger et al. Journal of General Virology 75: 301-307, 1994.
Flexner, et al., "Successful vaccination with a polyvalent live vector despite existing immunity to an expressed antigen", Nature, 335, No. 6187, pp. 259-262 (1988).
Cranage, et al., "Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus", The Embo Journal, 5, No. 11, pp. 3057-3063 (1986).
Forrester, et al., "Construction and Properties of a Mutant of Herpes Simplex Virus Type 1 with Glycoprotein H Coding Sequences Deleted", J. Virol.,66, No. 1, pp. 341-348 (1992).

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