Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2002-05-13
2008-08-26
Kemmerer, Elizabeth C. (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S320100, C435S252300, C435S254110, C435S325000, C536S023100, C536S023500, C530S350000, C530S351000
Reexamination Certificate
active
07416849
ABSTRACT:
The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
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Allen Kristina
Anisowicz Anthony
Graham James R.
Liu Wei
Morales Arturo
Drinker Biddle & Reath LLP
Kemmerer Elizabeth C.
Oscient Pharmaceuticals Corporation
Wyeth
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