Optical: systems and elements – Optical frequency converter – Harmonic generator
Reexamination Certificate
2005-07-26
2005-07-26
Lee, John D. (Department: 2874)
Optical: systems and elements
Optical frequency converter
Harmonic generator
C359S328000, C359S381000, C356S904000
Reexamination Certificate
active
06922279
ABSTRACT:
A harmonic generation microscopy employs a laser device that emits a laser beam having a predetermined wavelength that causes no autofluorescence in a biological sample and that, after excited, induces both the second and third harmonic waves. The laser beam is projected onto a sample and an observation beam from the sample is received. The observation beam is directed through a splitter to separate the second harmonic wave and the third harmonic wave both of which are then converted into corresponding electrical signals. The electrical signals are fed to a computer-based image processing equipment to form an image of the sample on the basis of the second and third harmonic waves.
REFERENCES:
patent: 4063804 (1977-12-01), Hellwarth et al.
patent: 5828459 (1998-10-01), Silberberg
patent: 6208886 (2001-03-01), Alfano et al.
patent: 6693257 (2004-02-01), Tanaka
patent: 2004/0135079 (2004-07-01), Moellmann
Two-Photon Laser Scanning fluorescence Microscopy Winfried Denk, James H. Strickler and Watt W. Webb, Science, New Series, vol. 248, Issue 4951 (Apr. 6, 1990), pp 73-76.
Second-harmonic imaging in the scanning optical microscope J. N. Gannaway and C. J. R. Sheppard, Optic Quantum Electron, 1978, vol. 10, pp. 435-439.
Nonlinear scanning laser microscopy by third harmonic generation Y. Barad, H. Eisenberg, M. Horowitz and Y. Silberberg, Applied Physics Letters, 1997, vol. 70, pp 922-924.
Chu Shi-Wei
Sun Chi-Kuang
Lee John D.
National Taiwan University
LandOfFree
Harmonic generation microscopy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Harmonic generation microscopy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Harmonic generation microscopy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3393793