Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-12-12
2006-12-12
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S008100, C530S300000, C530S326000, C530S382000, C530S345000, C427S414000
Reexamination Certificate
active
07148190
ABSTRACT:
We disclose haptotactic peptides having sequences homologous to specific portions of the carboxy terminal sequence of fibrinogen chains. The peptides derived from fibrinogen pre-Cγ chain possess activities of cell attraction or cell attachment to a surface to which the peptide is covalently bound.
REFERENCES:
patent: 4455290 (1984-06-01), Olexa et al.
patent: 4661471 (1987-04-01), Hawiger et al.
patent: 5372933 (1994-12-01), Zamarron et al.
patent: 5599790 (1997-02-01), Altieri et al.
patent: 6083902 (2000-07-01), Cederhom-Williams
patent: WO 95/29686 (1995-11-01), None
patent: WO 99/61041 (1999-12-01), None
Farrell, D. H. et al. (1994) Binding of recombinant fibrinogen mutants to platelets. J. Biol. Chem. vol. 269, pp. 226-231.
Fornace, A. J. et al. (1984) Structure of the human gamma-fibrinogen gene. Alternate mRNA splicing near the 3′ end of the gene produces gamma A and gamma B forms of gamma-fibrinogen. J. Biol. Chem. vol. 259, pp. 12826-12830.
Moroi, M. et al. (1998) Integrin-mediated platelet adhesion. Front Biosci. vol. 3, pp. 719-728.
Francis, C. W. et al. (1988) Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen. Proc. Natl. Acad. Sci. U S A. vol. 85, pp. 3358-3362.
Attachment 1 (www.bioon.com/book/biology/genomicglossaries/proteins—glossary.asp.htm), p. 1-1.
Redman et al. (2001) Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion. Ann. N. Y. Acad. Sci. vol. 936, pp. 480-495.
Chung, D., et al., (1983) , Characterization of Complementary Deoxyribonucleic Acid and Genomic Deoxyribonucleic Acid for the β Chain of Human Fibrinogen,Biochemistry, (22) pp. 3244-3250 (Exhibit 2).
Watala, C, et al., (1996), Microenvironmental changes in platelet membranes induced by the interaction of fibrinogen-derived peptide ligands with platelet integrins,Eur. J. Biochem., (235) pp. 281-288 (Exhibit 3).
International Search Report (Exhibit 4).
Gorodetsky Raphael
Marx Gerard
Cooper & Dunham LLP
Hadasit Medical Research Services & Development Company Ltd
Liu Samuel Wei
White John P.
LandOfFree
Haptotactic peprides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Haptotactic peprides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Haptotactic peprides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3717020