Haptens useful in evaluating inhibition of PNN elastase by N-sub

Details Haptens useful in evaluating inhibition of PNN elastase by N-sub Haptens useful in evaluating inhibition of PNN elastase by N-sub

1991-08-26

1994-01-04

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

435 71, 436543, 530367, 530386, 530405, 530807, 549469, 564 56, C07K 308, C07C27504, C07D30779, G01N 3368

Patent

active

052761398

ABSTRACT:
N-substituted azetidinones are a class of inhibitors of human leukocytes elastase which are known to be useful in the treatment of a wide variety of antiinflammatory and antidegenerative diseases. In inhibiting elastase, the therapeutic agents are shown to form a characteristic stable complex with the enzyme. In the radioimmune assay disclosed herein, the inhibitor-enzyme complex is advantageously hydrolyzed and specific product(s) of the hydrolysis are measured. The assays are useful in a clinical setting, for determining appropriate dosage and assessing the effectiveness of treatment.

REFERENCES:
patent: 4680391 (1987-07-01), Firestone et al.
Chemical Abstracts 75:35,848 (1971); 77: 135,029 (1972); 78:110,819 (1971); 115:126,395 (1991).
Chem Abstracts, vol. 78, No. 17, Apr. 30, 1973.
Chem Abstracts, vol. 115, No. 13, Sep. 30, 1991.

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