Haptens, tracers, immunogens and antibodies for immunoassays for

Details Haptens, tracers, immunogens and antibodies for immunoassays for Haptens, tracers, immunogens and antibodies for immunoassays for

1993-05-12

1994-10-18

Ceperley, Mary E.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Signal modification or steric inhibition

435 793, 436545, 436546, 436815, G01N 33542

Patent

active

053568206

ABSTRACT:
Disclosed is a substantially optically pure hapten, useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene. The hapten corresponds to a specified structural formula (IX).
Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten.
Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene.
Also disclosed is an improved immunoassay for determining dextropropoxyphene and/or nordextropropoxyphene in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining dextropropoxyphene and/or nordextropropoxyphene involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.

REFERENCES:
patent: 4012525 (1977-03-01), Murphy et al.
patent: 4025501 (1977-05-01), Leute
J. Gosling, Clin. Chem., vol. 36, No. 8, 1408-1427 (1990).
M. Fransioli et al., J. Anal. Toxicology, vol. 4, 46-48 (1980).

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