Haptens, tracers, immunogens and antibodies for carbazole and di

Details Haptens, tracers, immunogens and antibodies for carbazole and di Haptens, tracers, immunogens and antibodies for carbazole and di

1993-07-01

1995-11-07

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 78, 548447, 536 266, C12Q 168

Patent

active

054647460

ABSTRACT:
Novel tethered hapten intermediates and related conjugates based on carbazole and/or dibenzofuran, as well as methods for making and using such conjugates. Haptens based on the above core structures may be substituted at any position on the aromatic rings with a wide variety of substituents. Using tethered intermediates, immunogens, tracers, solid supports and labeled oligonucleotides are all described; as are methods for using the intermediates to prepare the conjugates, methods of using the conjugates to make and purify antibodies, as assay tracers, and in nucleic acid hybridization assays. Kits containing haptenated oligonucleotides and anti-hapten conjugates are also described.

REFERENCES:
patent: 5204374 (1994-04-01), Muller et al.
Lindquist et al. Carcinogenesis 10(12): 2187-95.

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