Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-10-03
2006-10-03
Le, Long V. (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S389800, C530S405000, C436S545000, C436S546000, C436S814000, C435S188000, C546S069000
Reexamination Certificate
active
07115718
ABSTRACT:
The invention provides a hapten derivatized with a crosslinker at the nitrogen of the 8β-carboxamide of 2-oxo-3-hydroxy LSD. The invention also provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material; a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least the 3-hydroxy-2-pyrrolidone structural epitope of 2-oxo-3-hydroxy LSD.
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Li, Z. et al., “New Synthesis and Characterization of (+)-Lysergic Acid Diethylamide (LSD) Derivatives and the Development of a Microparticle-Based Immunoassay for the Detection of LSD and Its Metabolites”, XP 002175870,Bioconjugate Chem., 1997, 8, 896-905.
Ratcliffe, W.A. et al., “Radioimmunoassay of Lysergic Acid Diethylamide (LSD) in Serum and Urine by Using Antisera of Different Specificities”,Clinical Chemistry, XP 002041570, 1977, 23(2), 169-174.
Benchikh Elouard
Fitzgerald Stephen Peter
Lamont John Victor
McConnell Robert Ivan
Haq Shafiqul
Le Long V.
Randox :abpratproes :o, oted
Woodcock & Washburn LLP
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