Haptens, immunogens and antibodies to oxycodone and its...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C530S388900, C530S389800, C530S404000, C530S405000, C546S043000

Reexamination Certificate

active

07026134

ABSTRACT:
Novel haptens, which can be conjugated to form immunogens, are of formula I, II or IIIwherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.

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Findlay, John W.A. et al.; “Relationships between Immunogen Structure and Antisera Specificity in the Narcotic Alkaloid Series”Clinical Chemistryvol. 27, No. 9 1981; pp. 1524-1535.
Klein, Peter et al.; “O3-(2-Carbomethoxyallyl) Ethers of Opioid Ligands Derived from Oxymorphone, Naltrexone, Etorphine, Diphrenorphine, Norbinaltorphimine, and Naltrindole. Unexpected O3Dealkylation in the Opioid Radioligand Displacement Assay”Journal of Medicinal Chemistryvol. 35, No. 24 1992; pp. 4589-4594.
Lester, M. G. et al.; “Vilsmeier Reactions with Cyclic Ketals of 14-Hydroxydihydrocodeinone and some New Cyclic Derivatives of 14-Hydroxydihydrocodeinone”Elsevier Science Publishers, Amsterdamvol. 21, No. 4 1965; pp. 771-778.

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