Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-07-29
1993-08-24
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
560173, 560177, 560194, C07D31186
Patent
active
052390861
ABSTRACT:
Disclosed is a substantially optically pure hapten, useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene. The hapten corresponds to a specified structural formula (IX).
Also disclosed is an immunogen derived from the hapten as well as an antibody raised in response to an immunogen derived from the hapten.
Also disclosed is a fluorescent tracer derived from a substantially optically pure compound corresponding to the hapten, the tracer being useful in an immunoassay for dextropropoxyphene and/or nordextropropoxyphene.
Also disclosed is an improved immunoassay for determining dextropropoxyphene and/or nordextropropoxyphene in a biological sample involving a step of contacting the sample with antibodies raised in response to the immunogen. Also disclosed is a fluorescence polarization immunoassay (FPIA) for determining dextropropoxyphene and/or nordextropropoxyphene involving a step of contacting the sample with antibodies raised in response to the immunogen, and/or involving a step of contacting the sample with a fluorescent tracer.
REFERENCES:
patent: 4025501 (1977-05-01), Leute
"Measurement of Dextropropoxyphene and Nordextropropoxyphene in Biological Fluids", by R. J. Flanagan et al., Human Toxicol, 3, 103S-114 S (1984).
"Detection of Methadone and Propoxyphene in Stored Tissue", by M. G. Fransioli et al., Journal of Analytical Toxicology, vol. 4, Jan./Feb. 1980, pp. 46-48.
Dubler Robert E.
Grote Jonathan
Kuhn Donna R.
Abbott Laboratories
Breininger Thomas M.
Pope Lawrence S.
Raymond Richard L.
Steele Gregory W.
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