Hapten-biotin conjugates and their use

Details Hapten-biotin conjugates and their use Hapten-biotin conjugates and their use

1991-04-10

1993-06-15

Kepplinger, Esther L.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

436500, 436540, 436544, 435 75, 5483041, 544267, 562447, G01N 33536, G01N 33541, C07D49504

Patent

active

052197646

ABSTRACT:
Hapten-biotin conjugates in which the hapten is linked with biotin via a spacer, which has 26 to 40 atoms in its chain and contains at least 5 heteroatoms, are novel and are suitable, in particular for use in a competitive homogeneous immunoassay in which the agglutination which occurs in the reaction is evaluated by turbidimetric or nephelometric measurements.

REFERENCES:
patent: 4617261 (1986-10-01), Sheldon, III et al.
patent: 4760142 (1988-02-01), Primes et al.
patent: 4898951 (1990-02-01), Symons
Green et al Biochem J. (1971) 125, 781-791.
Harlow et al Chapter 14, pp. 591-592 in Antibodies A Laboratory Manual Cold Spring Harbor (1988).

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