Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-12-24
1989-02-07
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
435121, 548411, C07D20996, A61K 3140, C12P 1710
Patent
active
048032174
ABSTRACT:
Hapalindolinone compounds are produced by the controlled aerobic fermentation of a cyanobacterium of the genus Fischerella, ATCC No. 53558. These compounds are antagonists of vasopressin and are useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia, and have the formula: ##STR1##
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Hirsch Charles F.
Pettibone Douglas J.
Schwartz Robert E.
Sigmund Janet M.
Berch Mark L.
Bernhardt F.
Caruso Charles M.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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