Hantaan virus strain ROK84/105 and vaccine therefor

Details Hantaan virus strain ROK84/105 and vaccine therefor Hantaan virus strain ROK84/105 and vaccine therefor

1989-11-16

1993-02-02

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 4352351, 435236, 435238, 435239, A61K 3912, C12N 700

Patent

active

051836580

ABSTRACT:
The present invention relates to Hantaan virus and a vaccine therefor. The Hantaan virus vaccine can be prepared as follows: The Hantaan virus ROK84/105 strain isolated from the human body as a seed strain, injected to one-day-old suckling mouse or rat, which is raised for about 10 days. Thereafter, the head of the mouse or rat is cut apart after paralyzing the mouse or rat to take the brain, the brain is treated with ethyl alcohol and protamine sulfate solution, the resultant is purified and inactivated, and an adjuvant is added to the final product.

REFERENCES:
H. W. Lee, "Korean Hemorrhagic Fever", Ebola Virus Hemorrhagic Fever, Copyright 1988, Elsevier North Holland Biomedical Press, S. R. Pattyn Editor, pp. 331-343.
H. W. Lee, "Korean Hemorrhagic Fever", Progress in Medical Virology, Copyright 1982, S. Karger (publishers) Basel, Switzerland, vol. 28, pp. 96-113.
H. W. Lee, 1982, "Hemorrhagic Fever with Renyl Syndrome (HFRS)", Scand. J. Infect, Dis. Suppl. 36:82-85.
H. W. Lee et al., 1980, "Management of Korean Hemorrhagic Fever", Medical Progress, Sep. issue, pp. 15-21.
Reference Document (Author or Authors unknown), published before Dec. 28, 1989, p. 345.
Yamanishi et al, Vaccine, vol. 6, pp. 278-282, Jun. 1988.
Lee et al, Biological Abstracts, Oct. 15, 1978 Ref. #46752.
French et al, Science, vol. 211, pp. 1046-1048, Mar. 6, 1981.
Hamada et al, Biological Abstract, vol. 81(8), 1986, Ref. #73451.
Lee et al, The Journal of Infectious Disease, vol. 146, No. 5, pp. 638-644, Nov. 1982.

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