Hansenula polymorpha yapsin deficient mutant strain and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S069100, C435S223000, C435S255600, C435S320100, C435S455000

Reexamination Certificate

active

10518377

ABSTRACT:
The present invention relates to a nucleic acid molecule comprising the HpYPS1 gene encodingH. polymorphayapsin1, a polypeptide encoded by the nucleic acid molecule, aH. polymorphamutant strain having reduced yapsin activity by mutation of the HpYPS gene encodingH. polymorphayapsin1, a recombinantH. polymorphastrain expressing a foreign protein produced by introducing a gene encoding the foreign protein into theH. polymorphamutant strain, and a process for preparing a foreign protein comprising culturing the recombinantH. polymorphastrain under conditions to express the foreign protein and isolating the foreign protein from the culture.

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English Language Abstract of KOREAN 102002-0017754.
English Language Abstract of KOREAN 10-2002-0088841.

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