Hammerhand ribozymes

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 231, 536 232, 435 16, 435 9131, 4353201, 514 44, C07H 2104, C12Q 168

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active

058408746

ABSTRACT:
Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a plant, animal or viral target RNA, a region of defined sequence and a base paired stem region.

REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
Been, M.D. et al., (1986) "One Binding Site Determines Sequence Specificity of Tetrahymena Pre-rRNA Self-Splicing, and RNA Enzyme Activity," Cell 47: 207-216 (Exhibit 2).
Boehm, S., (1987), "Similarities between a predicted secondary structure for the M.sub.1 RNA ribozyme and the tRNA binding center of 16S rRNA from E.coli" FEBS Letters, 220: 283-287 (Exhibit 3).
Breuning, G. et al., (1987) "Non-Enzymatic Cleavage and Ligation of a Plant Satellite RNA," Plant Molecular Biology 140: 495-502 (Exhibit 4).
Breuning, G. et al., (1988A) "Replication of Small Satellite RNAs and Viroids: Possible Participation of Nonenzymic Reactions," RNA Genetics II: 127-145 (Exhibit 5).
Breuning, G. et al., (1988B) "Small RNA Autolytic Cleavage and Ligation," Structure and Expression 1: 239-248 (Exhibit 6).
Breuning, G. (1989) "Compilation of Self-Cleaving Sequences from Plant Virus Satellite RNAs and Other Sources", Methods in Enzymology 180: 546-558 (Exhibit 7).
Buzayan, J. et al., (1986) "Non-Enzymatic Cleavage and Ligation of RNAs Complementary to a Plant Virus Satellite RNA," Nature 323: 349-353 (Exhibit 8).
Buzayan, J. et al., (1988A) "RNA Mediated Formation of A Phosphorothioate Diester Bond," Biochemical and Biophysical Research Communication 156: 340-347 (Exhibit 9).
Buzayan, J. et al., (1988B) "Autolytic Processing of a Phosphorothioate Diester Bond," Nucleic Acids Research 16(9): 4009-4023 (Exhibit 10).
Cech, T.R., (1987) "The Chemistry of Self-Splicing RNA Enzymes", Science 236: 1532-1539 (Exhibit 11).
Chuat, J. et al., (1989) "Can Ribozymes Be Used To Regulate Procaryote Gene Expression?", Biochemical and Biophysical Research Communications 162: 1025-1029 (Exhibit 13).
Cotten, M. et al., (1989) "Ribozyme Mediated Destruction of RNA in vivo" The EMBO Journal 8: 3861-3866 (Exhibit 14).
Eckner, R. et al., (1991) "Mature mRNA 3' End Formation Stimulates RNA Export from the Nucleus" The EMBO Journal 10: 3513-3522 (Exhibit 15).
Forster, A.C. et al., (1988) "Self-Cleaving Viroid and Newt RNAs May Only Be As Dimers" Nature 334: 265-267 (Exhibit 16).
Forster, A.C. and Symons R.H., (1987A) "Self-Cleavage of Plus and Minus RNAs of a Virusoid and a Structural Model for Active Sites" Cell 49: 211-220 Exhibit (17).
Forster, A.C. et al., (1987B) "Self-Cleavage of Virusoid Is Performed by the Proposed 55-Nucleotide Active Site" Cell 50: 9-16 (Exhibit 18).
Gerlach, W. et al., (1986) "Satellite Tobacco Ringspot Virus RNA: Biological Activity of DNA Clones and Their in Vitro Transcripts," Virology 151: 172-185 (Exhibit 19).
Guerrier-Takada, C. et al., (1983) "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35: 849-857 (Exhibit 20).
Hampel, A. et al., (1988) "A Model for the RNA Catalyzed Cleavage of a Plant Satellite RNA," Journal of Cellular Biochemistry 12D: 31 (Exhibit 21).
Haseloff, J. and Gerlach, W.L., (1989) "Simple RNA enzyme with new and highly specific endoribonuclease activities" Nature 334: 585-591 (Exhibit 22).
Huillier, A. et al., Ribozyme mediated suppression of .alpha.lactalbumin Expressed in C1271 Cells by T7/Vaccinia Virus (Abstract from conference proceedings) (Exhibit 23).
Hutchins, C.J. et al., (1986) "Self-cleavage of plus and minus RNA transcripts of avocado sunblotch virus" Nucleic Acids Research, 14: 3627-3635 (Exhibit 24).
Kikuchi, Y. et al., (1991) "Site-specific cleavage of natural mRNA sequences by newly designed hairpin catalytic RNAs" Nucleic Acids Research 19: 6751-6755 (Exhibit 25).
Koizumi, et al., (1988) "Construction of a series of several self-cleaving RNA duplexes using synthetic 21-mers" FEBS Letters 228: 228-230 (Exhibit 26).
Koizumi, et al., (1989) "Design of RNA enzymes distinguishing a single base mutation in RNA" Nucleic Acids Research 17: 7059-7071 (Exhibit 27).
Lamb, J.W. and Hay, R.T., (1990) "Ribozymes that cleave potato leafroll virus RNA within the coat protein and polymerase genes", J. Gen. Virol. 71: 2257-2264 (Exhibit 28).
McClain et al., (1987) "Model Substrates for an RNA Enzyme" Science 238: 527-530 (Exhibit 29).
Miller, W.A. et al., (1991) "A Satellite RNA of Barley Yellow Dwarf Virus Contains a Novel Hammerhead Structure in the Self-Cleavage Domain" Virology 183: 711-720 (Exhibit 30).
Muesing, M. et al., (1985) "Nucleic Acid Structure and Expression of the Human AIDS/Lymphadenopathy Retrovirus," Nature 313: 450-458 (Exhibit 31).
Prody, G. et al., (1986) "Autolytic Processing of Dimeric Plant Virus Satellite RNA," Science 231: 1577-1580 (Exhibit 32).
Ruffner, D.E. et al., (1989) "Studies on the hammerhead RNA self-cleaving domain" Gene 82: 31-41 (Exhibit 33).
Ruffner, D.E. et al., (1990) "Sequence Requirements of the Hammerhead RNA Self-Cleaving Reaction" Biochemistry 29: 10695-10702 (Exhibit 34).
Sampson et al., (1987) "Characterization of Two-RNA catalyzed RNA Cleavage Reactions" Cold Spring Harbor Sym. Quant. Biol. 52: 267-275 (Exhibit 35).
Sarver, N. et al., (1990) "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science, 247: 1222-1224 (Exhibit 36).
Saxena, S. et al., (1990) "Ribozymes Correctly Cleave a Model Substrate and Endogenous RNA in vivo" J. Biol. Chem. 265: 17106-17109 (Exhibit 37).
Scanlon, K. et al., (1991) "Ribozyme-mediated cleavage of c-fos RNA reduces gene expression of DNA synthesis enzymes and metallothionein" Proc. Natl. Acad. Sci. USA, 88: 10591-10595 (Exhibit 38).
Sheldon, C.C. & Symons, R.H., (1989) "RNA stem stability in the formation of a self-cleaving hammerhead structure" Nucleic Acids Research 17: 5665-5678 (Exhibit 39).
Sheldon, C.C. & Symons, R.H., (1989) "Mutagenesis analysis of a self-cleaving RNA" Nucleic Acids Research, 17: 5679-5686 (Exhibit 40).
Symons, R.H., (1989) "Self-cleavage of RNA in the replication of small pathogens of plants and animals" TIBS 14: 445-450 (Exhihbit 41).
Tabler, M. & Tsagris, M., (1991) "Catalytic antisense RNAs produced by incorporating ribozyme cassettes into cDNA" Gene 108: 175-183 (Exhibit 42).
Uhlenbeck et al., (1987) "A small catalytic oligonucleotide" Nature 328: 596-600 (Exhibit 43).
Walbot, V. et al., (1988) "Plant Development and Ribozymes for Pathogens," Nature 334: 196-197 (Exhibit 44).
Waring, R. et al., (1985) "The Tetrahymena rRNA Intron Self-Splices in E. Coli: In Vivo Evidence for the Importance of key Base-Paired of RNA for RNA Function," Cell 40: 371-380 (Exhibit 45).
Zaug, A.J. & Cech, T.R., (1986A) "The Intervening Sequence RNA of Tetrahymena is an Enzyme"Science 231: 473-474 (Exhibit 46); and.
Zaug, A.J. et al., (1986B) "The Tetrahymena ribozyme acts like an RNA restriction endonuclease" Nature 234: 429-433 (Exhibit 47).

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