Halomethyl derivatives of gamma-aminobutyric acid and related co

Details Halomethyl derivatives of gamma-aminobutyric acid and related co Halomethyl derivatives of gamma-aminobutyric acid and related co

1977-09-28

1982-04-20

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

544 30, 560 29, 560 30, 560 38, 560 39, 560159, 560161, 560172, 562444, 562448, 562449, 562561, 564164, 564165, 564197, 564198, C07C10110, C07C10118

Patent

active

043260713

ABSTRACT:
Novel compounds of the following general formula are useful pharmacological agents: ##STR1## wherein Y is FCH.sub.2 - or F.sub.2 CH-; R.sub.1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, -NR.sub.10 R.sub.11 wherein each of R.sub.10 and R.sub.11 is hydrogen or a straight or branched alkyl group of from 1 to 4 carbon atoms or ##STR2## wherein R.sub.12 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR3## wherein R.sub.8 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and n is the integer 2 or 3; pharmaceutically acceptable salts and individual optical isomers thereof.

REFERENCES:
patent: 2523470 (1950-09-01), Kropa et al.
patent: 3477933 (1969-11-01), Stamm et al.
patent: 3830922 (1974-08-01), Witzel
patent: 3960927 (1976-06-01), Metcalf et al.
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 335.

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