Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1982-09-21
1986-08-05
Hollrah, Glennon H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544194, 544211, 544213, 544224, 544239, 544240, 544241, 544317, 544320, 544321, 544322, 544327, 544330, 544331, 544332, 544408, 544409, 546297, 546306, C07D23942, A61K 31505
Patent
active
046044655
ABSTRACT:
Compounds useful for inhibiting gastric acid secretion and for the treatment of peptic ulcers caused or exacerbated by gastric acidity having the following formula (I): ##STR1## in which R.sup.1 and R.sup.2, are H, C.sub.1-10 alkyl, C.sub.3-8 cycloalkyl or cycloalkylalkyl in which the alkyl part is C.sub.1-6 and the cycloalkyl part is C.sub.3-8, each of the alkyl, cycloalkyl and cycloalkylalkyls being optionally substituted by one or more halogens selected from F, Cl and Br, provided that at least one of R.sup.1 and R.sup.2 is a halogen substituted alkyl, cycloalkyl or cycloalkylalkyl and provided that there is no halogen substituent on the carbon directly attached to the nitrogen; and X, m, Y, n and R.sup.3 are as described in the specification; and the pharmaceutically-acceptable acid-addition salts thereof. Processes for producing compounds of formula (I), pharmaceutical compositions containing them, methods of utilizing such compositions and intermediates useful for synthesizing compounds of formula (I) are also described.
REFERENCES:
patent: 4336255 (1982-06-01), Ladd
patent: 4464378 (1984-08-01), Yellin et al.
Edwards Philip N.
Large Michael S.
Yellin Tobias O.
Hollrah Glennon H.
ICI Americas Inc.
Imperial Chemical Industries Limited
Turnipseed James H.
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