Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-11-12
1982-12-07
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424250, 424251, 4242484, 424263, 424269, 544360, 544361, 544322, 544331, 544332, 544239, 544405, 544194, 544111, 544112, 546304, 546312, 546192, 546210, C07D23924, A61K 31495, A61K 31505
Patent
active
043627285
ABSTRACT:
Compounds useful for inhibiting gastric acid secretion and for the treatment of peptic ulcers caused or exacerbated by gastric acidity having the following formula (I): ##STR1## in which R.sup.1 and R.sup.2, are H, C.sub.1-10 alkyl, C.sub.3-8 cycloalkyl or cycloalkylalkyl in which the alkyl part is C.sub.1-6 and the cycloalkyl part is C.sub.3-8, each of the alkyl, cycloalkyl and cycloalkylalkyls being optionally substituted by one or more halogens selected from F, Cl and Br, provided that at least one of R.sup.1 and R.sup.2 is a halogen substituted alkyl, cycloalkyl or cycloalkylalkyl and provided that there is no halogen substituent on the carbon directly attached to the nitrogen; and X, m, Y, n and R.sup.3 are as described in the specification; and the pharmaceutically-acceptable acid-addition salts thereof. Processes for producing compounds of formula (I), pharmaceutical compositions containing them, methods of utilizing such compositions and intermediates useful for synthesizing compounds of formula (I) are also described.
REFERENCES:
patent: 4165377 (1979-08-01), Jones et al.
patent: 4165378 (1979-08-01), Gilman et al.
patent: 4200578 (1980-04-01), Algieri et al.
patent: 4234735 (1980-11-01), Jones et al.
patent: 4239908 (1980-12-01), Adelstein
patent: 4242350 (1980-12-01), Yellin et al.
patent: 4242351 (1980-12-01), Yellin et al.
patent: 4283408 (1981-08-01), Hirata et al.
Edwards Philip N.
Large Michael S.
Yellin Tobias O.
ICI Americas Inc.
Imperial Chemical Industries Ltd.
Levy David J.
Rizzo Nicholas S.
Sheehan John M.
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