Halogenophenyl glyceride esters for use in the prophylaxis and/o

Details Halogenophenyl glyceride esters for use in the prophylaxis and/o Halogenophenyl glyceride esters for use in the prophylaxis and/o

1983-06-06

1986-05-06

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

2604107, 560138, A61K 31235, C07C 6900

Patent

active

045872627

ABSTRACT:
The invention concerns novel glyceride esters of anti-bacterial halogenated phenols having the formula I in which Ra and Rb are independently (3-20C)alkyl or (3-20C)alkenyl; Rc and Rd are independently chloro or bromo; Re is hydrogen, chloro or bromo; and A is (1-6C)alkylene optionally bearing one or two (1-4C)alkyl substituents.
The esters are of use in the prophylaxis and/or therapy of acne vulgaris. Pharmaceutical compositions for topical administration and processes for the manufacture of the esters are also provided.

REFERENCES:
patent: 3506720 (1970-04-01), Model et al.
patent: 3576843 (1971-04-01), Model
E. Franz et al., J. International Medical Research, 1978, vol. 6, pp. 72-77.
Arnould et al., "Chem. Abst.", vol. 101, No. 101: 6818y (1984).
I.C.I. "Chem. Abst.", vol. 101, No. 101: 110556x, Abstract of Japanese Koki 59 51,240.

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