Halogenohydrates of N,N-disubstituted derivatives of piperazine

Details Halogenohydrates of N,N-disubstituted derivatives of piperazine Halogenohydrates of N,N-disubstituted derivatives of piperazine

1977-02-17

1982-04-06

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Dentifrices

Fluorine or fluorine compound containing

544374, 544401, A61K 718, C07D29508

Patent

active

043235506

ABSTRACT:
Halogenohydrates of N,N'-disubstituted derivatives of piperazine of the general formula: ##STR1## wherein YR is a hydroxylalkyl, polyhydroxyalkyl or epoxyalkyl wherein Y is a hydroxy, polyhydroxy or epoxy group, R is lower alkyl C.sub.2 -C.sub.4, and X is a member selected from the group consisting of fluorine, bromine, chlorine and iodine. The compounds have useful anticariogenic properties.

REFERENCES:
patent: 3124512 (1964-03-01), Schmid et al.
patent: 3277118 (1966-10-01), Schmid et al.
Sharts & Sheppard-Organic Reactions-vol. 21-pp. 201-204; 216-219 (1974) (John Wiley & Sons, Inc., New York).
Elderfield-Heterocyclic Compounds-vol. 1-pp. 23-24 (1950) (John Wiley & Sons, Inc., New York).
Paul et al. J. Med. Chemistry, vol. 16, No. 12, 1391-1394 (1973).
Gardner et al., J. Amer. Chem. Soc., vol. 55, 3823 (1933).

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