Halogenobenzyl aminopropionic acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S205000, C548S236000

Reexamination Certificate

active

06933309

ABSTRACT:
A halogenobenzylaminopropionic acid derivative represented by the following formula (1):or a pharmaceutically acceptable salt of the derivative, and a drug containing the same as an active ingredient for treating diabetes, hyperlipidemia, or similar pathological conditions.

REFERENCES:
patent: 96/38415 (1996-12-01), None
patent: 97/31907 (1997-09-01), None
patent: 00/08002 (2000-02-01), None
Diabetes Care (US), American Diabetes Association, vol. 21, pp. 641-648 1998.
The Lancet (UK), Lancet, vol. 357, pp. 905-910 2001.
Kahn et al. DIABETOLOGY (DE), European Association for Study of Diabetes, vol. 39 (suppl), p. A53 1996.
G. Riccardi et al., “Effects of bezafibrate on insulin secretion and peripheral insulin sensitivity in hyperlipidemic patients with and without diabetes,”Atherosclerosis, 75 (1989), Elsevier Scientific Publishers Ireland, Ltd., pp. 175-181.
G. Paragh et al., “Treatment Possibility of Hypercholesterolaemia Associated with Hypertriglyceridaemia,”Acta Biologica Hungarica48 (3) (1997), pp. 359-367.
M. Yoshinari et al., “Effect of gemfibrozil on serum levels of prostacycin and precursor fatty acids in hyperlipidemic patients with Type 2 diabetes,” Diabetes Research and Clinical Practice 42 (1998), pp. 149-154.
Y. Kawamatsu et al., “Studies on Antihyperlipidemic Agents,” Central Research Division, Takeda Chemical Industries, Ltd., Osaka (Japan) pp. 454-459.

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