Halogenation of cephalexin with haloperoxidase from Rathayibacte

Details Halogenation of cephalexin with haloperoxidase from Rathayibacte Halogenation of cephalexin with haloperoxidase from Rathayibacte

1994-12-20

1996-12-31

Rollins, John W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435189, 43525232, C12P 3500, C12N 902, C12N 120

Patent

active

055893546

ABSTRACT:
An enzyme preparation that exhibits cephalosporin haloperoxidase activity is isolatable from a microorganism species of the Rathayibacter genus. This enzyme preparation can convert cephalexin to a halogenated cephalosporin antibiotic in a single step. A particular, unique microorganism that can provide the cephalosporin haloperoxidase enzyme preparation is Rathayibacter biopuresis.

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H. I. Zgurskaya et al., "Rathayibacter gen. nov., Including the Species Rathayibacter rathayi comb. nov., Rathayibacter tritici comb. nov., Rathayibacter iranicus comb. nov., and Six Strains from Annual Grasses," Int'l J. of Systematic Bacteriology 43(1): 143-149 (Jan., 1993).
M. A. Pickard et al., "Chloroperoxidase, a Peroxidase with Potential," J. of Industrial Microbiology, pp. 235-242 (1991).
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