Halogenation catalyst

Details Halogenation catalyst Halogenation catalyst

2000-05-15

2001-03-27

Siegel, Alan (Department: 1621)

C562S840000, C562S862000, C546S315000, C570S258000, C570S261000

Reexamination Certificate

active

06206819

ABSTRACT:

The present invention relates to N,N-disubstituted formamides as halogenation catalysts and use of those catalysts for transforming organic hydroxyl and thiol groups to organohalides.
Many reactions for the conversion of organic hydroxyl and thiol groups to organohalides (for example, the preparation of carboxylic acid chlorides from carboxylic acids) are enhanced by the presence of N-alkylated formamides. Often such reactions require the presence of such catalysts. N,N-dimethyl formamide is one of the most commonly used. Unfortunately, under standard halogenation conditions, the use of N,N-di-loweralkyl formamides results in the formation of N,N-di-loweralkylcarbamoyl halides, which have been found to be animal carcinogens. Such halides are particularly hazardous due to their high volatility. U.S. Pat. No. 4,880,576 discloses N,N-dialkylformamides as chlorination catalysts wherein one alkyl group is a C
1
-C
4
alkyl group, with methyl the preferred group, and the other alkyl group contains at least nine carbon atoms. Use of such catalysts avoids the formation of highly volatile N,N-dialkylcarbamoyl chlorides. However, one limitation in the utility of such catalysts is obtaining the appropriate secondary amine wherein one alkyl group is small, methyl preferred, and the other is large, greater than nine carbons. Furthermore, although volatility is reduced, it is not eliminated so there is still risk to workers and to the environment through exposure to any N,N-dialkylcarbamoyl halide which may be formed.
We have discovered that it is not necessary to limit one, or both, of the alkyl groups of the formamide to less than four carbons in order to maintain halogenation catalyst activity. When the alkyl groups are both large, any N,N-dialkylcarbamoyl halide which may be formed during the halogenation reaction will have very low volatility resulting in less risk to workers and to the environment.
The present invention is the use as a halogenation catalyst of a compound, or mixture of compounds, of formula I:
wherein R
1
and R
2
are independently selected from:
a. unsubstituted or substituted C
5
-C
30
alkyl, C
5
-C
30
alkenyl, C
5
-C
30
alkynyl, and joined groups; and
b. unsubstituted or substituted amino and polyaminoalkyl and amino and polyaminoalkenyl;
wherein the substituents are independently selected from any functional group which does not react with the substrate to be halogenated or the halogenation agent to be used. Examples of such substituents include alkyl, aryl, halogen, alkoxy, cyano, nitro, formyl and haloalkyl.
A second embodiment of this invention is the use as a halogenation catalyst of a compound, or mixture of compounds, of formula I:
wherein one of R
1
and R
2
is independently selected from:
a. unsubstituted or substituted C
1
-C
30
alkyl, C
2
-C
30
alkenyl, C
2
-C
30
alkynyl, and joined groups; and
b. unsubstituted or substituted amino and polyaminoalkyl and amino and polyaminoalkenyl;
wherein the substituents are independently selected from any functional group which does not react with the substrate to be halogenated or the halogenation agent to be used;
and the other of R
1
and R
2
is a polymer.
The terms “alkyl”, “alkenyl”, and “alkynyl” include straight chain, branched chain, and cyclic groups. The term “aryl” means phenyl, naphthyl, and five and six membered aromatic heterocycle. The term “joined” means that the R
1
and R
2
groups together with the nitrogen to which they are attached form a cyclic group such as piperidine and 1,3-di-4-piperidylpropane. The terms “polyaminoalkyl” and “polyaminoalkenyl” mean an alkyl or alkenyl substituted with one or more amino groups. Such amino groups may be primary, secondary, or cyclic amino groups. The amino groups may be of different types within the same polyaminoalkyl or polyaminoalkenyl. Examples of such groups include diaminoalkyls of the formula R
1
N(CHO)-alkyl-N(CHO)R
2
, wherein R
1
and R
2
are as defined above, triaminoalkyls such as bis-(3-aminopropyl)amine, and polyaminoalkyls containing cyclic amine groups. The term “polymer” means any polymer functionalized with one or more amino groups in which the amino group is capable of forming a formamide and the resulting formamide functionalized polymer will not react under the anticipated halogenation reaction conditions. Examples of such polymers include weak base styrenic and acrylic anion exchange resins. Preferred polymers include functionalized ion exchange resins.
Alkyl groups are preferred R
1
and R
2
groups. Alkyl groups wherein the groups contain more than ten carbon atoms are more preferred because the resulting halogenated product is easily separated from the catalyst. Because of their low cost and high molecular weight, catalysts formed using mixed amines wherein the alkyl groups contain from twelve to twenty-four carbons, such as amines derived from natural fats, are most preferred.
Another embodiment of this invention is a method for converting a substrate to an organohalide, comprising the steps of:
a. forming a mixture comprising the substrate, a halogenating agent, and one or more catalysts of the formula:
wherein R
1
and R
2
are independently selected from:
i. unsubstituted or substituted C
5
-C
30
alkyl, C
5
-C
30
alkenyl, C
5
-C
30
alkynyl, and joined groups; and
ii. unsubstituted or substituted amino and polyaminoalkyl and amino and polyaminoalkenyl;
wherein the substituents are independently selected from any functional group which does not react with the substrate to be halogenated or the halogenating agent; and
b. maintaining the mixture at a temperature wherein formation of the organohalide occurs at an acceptable rate.
An alternative embodiment of this invention is a method for converting a substrate to an organohalide, comprising the steps of:
a. forming a mixture comprising the substrate, a halogenating agent, and one or more catalysts of the formula:
wherein one of R
1
and R
2
is independently selected from:
i. unsubstituted or substituted C
1
-C30 alkyl, C
2
-C
30
alkenyl, C
2
-C
30
alkynyl, and joined groups; and
ii. unsubstituted or substituted amino and polyaminoalkyl and amino and polyaminoalkenyl;
wherein the substituents are independently selected from any functional group which does not react with the substrate to be halogenated or the halogenating agent;
and the other of R
1
and R
2
is a polymer; and
b. maintaining the mixture at a temperature wherein formation of the organohalide occurs at an acceptable rate.
The term “substrate” means an organic compound containing one or more hydroxyl or thiol groups known to those skilled in the art to be capable of replacement by a halogen using typical halogenation agents. Examples of such substrates include carboxylic acids such as benzoic acid, hexanoic acid, trichloroacetic acid, and succinic acid; N-heterocyclic compounds which carry a hydroxyl group adjacent to the nitrogen, or their tautomeric forms, such as 2-hydroxypyridine, 2,6-dihydroxy4-phenyl-1,3,5-triazine, and 8-hydroxyquinoline; phenols such as picric acid; heterocyclic thiols such as thiazole-2-thiol; and sulfonic acids. The mixture may be formed by combining the components at the same time or by gradually adding one or more of the components. The preferred method of forming the mixture is to gradually add the halogenation agent to a premix of the remaining components. In such cases, the temperature of the premix may be at, above, or below the temperature of step b.
The halogenation reaction may also be used for other types of conversions such as benzaldehyde to benzal chloride, certain dehydration reactions, halogenation of nucleosides and nucleotide coupling, preparation of alkyl halides from alcohols, and the conversion of secondary amides to iminochlorides. The catalyst of this invention is particularly useful for halogenating substrates such as trichloroacetic, terephthalic, and pyridine dicarboxylic acids which are difficult to halogenate in the absence of a catalyst.
The method may be conducted in the absence or presence of a solvent. When a solvent is used it should be reasonab

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